The southbound lanes of Highway 41 at Hillsdale Road in Vanderburgh County were closed for a short time on Monday while first responders worked a crash with injuries.
Evansville Central Dispatch said the crash was reported around 6:00 p.m.
The Vanderburgh County Sheriff's Office was at the scene of the crash and released an image of a car flipped upside down.
The extent of the injuries sustained in the crash remains unknown at this time.
The sheriff's office said that the road had reopened on Monday about an hour after the crash.