Ryan Tannehill threw for 264 yards and a touchdown and ran for another score and the Tennessee Titans never trailed Sunday, holding off the Las Vegas Raiders 24-22 for their first victory this season. Derrick Henry also ran for 85 yards and a touchdown. Henry also added 58 yards more receiving as the Titans (1-2) avoided their worst start since 2009 when they lost the first six games. The Raiders (0-3) are off to their worst start since 2018. The Raiders had every chance to get back in this game in the second half as they blanked Tennessee after halftime. Derek Carr's 2-point conversion pass was broken up. The Titans recovered the onside kick to clinch.
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Roquan Smith set up Cairo Santos’ game-ending field goal when he intercepted Davis Mills deep in Houston territory, and the Chicago Bears beat former coach Lovie Smith and the Texans 23-20. Khalil Herbert ran for a career-high 157 yards and two touchdowns. The Texans had third-and-1 at their 26 when defensive tackle Angelo Blackson tipped a pass intended for Rex Burkhead. Smith, who missed practice all week because of a hip injury, intercepted it at the 30 and returned it to the 12. Chicago had Herbert run, then downed the ball twice before Santos nailed a 30-yarder as time expired.
Matt Ryan threw a 12-yard touchdown pass to rookie Jelani Woods with 24 seconds left to give the Indianapolis Colts a 20-17 comeback victory over the Kansas City Chiefs.
Austin Burton threw three touchdown passes in his first start at Purdue and led the Boilermakers to a badly-needed 28-26 victory over Florida Atlantic.
Will Levis tied a career best with four touchdown passes, including critical scores of 70 and 40 yards to Barion Brown and Tayvion Robinson, respectively, after halftime, and No. 8 Kentucky held off Northern Illinois 31-23.
Ben Bryant passed for 314 of his 354 yards in the first half with a career-high four touchdowns, and Tyler Scott had career-highs with 185 yards and three TDs, as Cincinnati defeated Indiana 45-24. Bearcats nose tackle Dominique Perry had a 14-yard fumble return TD helpi
Stuart Fairchild homered and Luis Cessa tossed five shutout innings to lead the Cincinnati Reds to a 3-0 win over the St. Louis Cardinals.
Trevor Lawrence threw two touchdown passes to Christian Kirk, and Jacksonville dominated short-handed Indianapolis 24-0 on Sunday for its eighth consecutive home victory in the series.
Garrett Shrader hit Oronde Gadsden II for a 25-yard touchdown pass with seven seconds left to lift Syracuse to a 32-29 win over Purdue. That capped a wild fourth quarter of dramatic lead changes. Syracuse led 10-9 after three quarters. The Orange improved to 3-0, its best start since 2018. Purdue fell to 1-2. Aidan O’Connell’s 12-yard touchdown pass to tight end Payne Durham with 51 seconds left in the game gave the Boilermakers a 29-25 advantage and seemed to seal it for Purdue. O’Connell completed 38 of 54 passes for 415 yards and three touchdowns. Charlie Jones caught 11 passes for 188 yards and one score for the Boilermakers.
Will Levis accounted for three touchdowns, Kavosiey Smoke ran for a score and No. 9 Kentucky shook off a slow start to shut out Youngstown State 31-0 on Saturday.